HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-2-fluoro-4-iodobenzene → 1-Chloro-2-fluoro-4-[(4-pentylphenyl)ethynyl]benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-2-fluoro-4-iodobenzene | HCID 2736563 | — |
| Reactant | 1-Ethynyl-4-pentylbenzene | HCID 2775131 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Diethylamine | HCID 8021 | — |
| Product | 1-Chloro-2-fluoro-4-[(4-pentylphenyl)ethynyl]benzene | HCID 15745230 | — |
Reaction Steps
0.2 mmol of Pd(PPh3)2Cl2 and 0.1 mmol of CuI are added to a mixture of 0.01 mol of 4-pentylphenylacetylene, 0.01 mol of 3-fluoro-4-chloro-iodobenzene and 40 ml of diethylamine at room temperature and stirred for 12 hours. After completion of the reaction, the suspension is filtered, and the filtrate is concentrated by evaporation. Purification by chromatography and/or crystallization gives 4-pentyl-3'-fluoro-4'-chloro tolan having C 49.6° I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05194178 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-27b81805cbca4584a94a315c6f563575 |
| Source note | uspto-grants-1993_03 |