4-(Benzodioxan-5-yl)-1-(indan-2-yl)piperazine → Eltoprazine

HRID 1613567Notes

Reaction equation

HRID 1613567 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([N:11]3[CH2:16][CH2:15][N:14](C4CC5C(=CC=CC=5)C4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3][CH2:2]1.S(C1C=CC(C)=CC=1)(OC1CC2C(=CC=CC=2)C1)(=O)=O>>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 1327874-(Benzodioxan-5-yl)-1-(indan-2-yl)piperazineHCID 70214742-Indanyl p-toluenesulfonate

Product 1

HCID 65853EltoprazineYield 11%

Procedure

4-(benzodioxan-5-yl)-1-(indan-2-yl)-piperazine, m.p. (M.K): 168°-171° C., from indan-2-yl tosylate [cf. Bull. Soc. Chem. (1962), p. 51] and N-(benzodioxan-5-yl)piperazine (yield: 11%).

Workup

  1. custom168°-171° C.

Sources & evidence

ORD record
ord-cae0e822fc014a0790dc668a70df5147
Source dataset
uspto-grants-1993_03
Patent number
US05194437

Reaction notes

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