HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → Pentanobenzeneacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Benzocycloheptan-1-one | HCID 21703317 | — |
| Reactant | 1-Ethoxycarbonylmethylbenzocycloheptane | HCID 53758794 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Pentanobenzeneacetic acid | HCID 18918733 | — |
Reaction Steps
(Benzocyclohept-1-en-1-yl)-acetic acid was prepared from 1-ethoxycarbonylmethylbenzocyclohept-1-ene, which was itself prepared from benzocycloheptan-1-one treated with ##STR11## and NaH in tetrahydrofuran, followed by separation of the two exocyclic unsaturated cis- and trans-isomers also formed, the separation being carried out by flash chromatography on silica gel with toluene as eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05194437 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-5c94360e4a7e40f3bb5d5ec38d85b435 |
| Source note | uspto-grants-1993_03 |