Pyridine, 2-[(trimethylsilyl)oxy]- → HCID 67883783, compound

Participants

Reaction Steps

6.40 g (20 mmol) of tetrabutylammonium fluoride trihydrate are added to a mixture of 3.24 g (20 mmol) of 4,5-epoxy-2,3,4,5-tetrahydro-1-benzoxepin and 10 g (60 mmol) of 2-trimethylsilyoxy-pyridine, and the mixture is heated at 80°-90° C. with stirring. After a reaction time of 5 hours, the mixture is slowly stirred into ice-water, and the precipitated solid is filtered off with suction and recrystallized from methanol with the addition of small amounts of dioxane. Crystals of melting point 232°-234° C. are obtained.

Provenance & Evidence