Sodium → 4,5-Epoxy-7-nitro-2,3,4,5-tetrahydro-benzoxepin

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Reaction Steps

2.65 g (0.115 mole) of metallic sodium are dissolved in 220 ml of methanol and, while stirring, a solution of 31.7 g (0.11 mole) of trans-4-bromo-5-hydroxy-7-nitro-2,3,4,5-tetrahydro-1-benzoxepin in 230 ml of methanol is added dropwise at room temperature. After 2.5 hours the precipitated solid is filtered off with suction and washed with methanol, and the filtrate is evaporated in vacuo. The residue is a solid of melting point 121°-123° C.

Provenance & Evidence