p-Fluoronitrobenzene → 4-(5-Benzyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl)nitrobenzene

Participants

Reaction Steps

The title compound was prepared in 79% yield from 2-benzyl-1,2,5-thiadiazolidine-1,1-dioxide and 1-fluoro-4-nitrobenzene using a similar method to that described for Example 20 (step 1). The crude product was crystallised from ethyl acetate to give a yellow solid; mp 164°-165° C.; δH (360 MHz, DMSO-d6) 8.30 (2H, d, J=9.2 Hz, Ar--H), 7.40 (5H, m, Ph), 7.33 (2H, d, J=9.2 Hz, Ar--H), 4.31 (2H, s, PhCH2 --), 3.98 (2H, t, J=6.4 Hz, --CH2 --), 3.49 (2H, t, J=6.4 Hz, --CH2 --); m/z (EI) 333 (M+).

Provenance & Evidence