Sulfuric Acid → 2-Phenyl-4-(pyrid-3-yl)-4-ethenyl-5-(2-chlorophenyl)-1,3-dioxolane

Participants

Reaction Steps

3 g (0.018 mol) of 3-(pyrid-3-yl)-4-(2-chlorophenyl)but-1-ene-3,4-diol were dissolved in 50 ml of benzaldehyde dimethyl acetal. 1 ml of concentrated H2SO4 was then added and the mixture was heated to 80°-90° C. The excess benzaldehyde dimethyl acetal was distilled off under reduced pressure, together with the resulting methanol. The crude product was dissolved in methylene chloride and the solution was neutralized with NaHCO3 solution. After the solvent had been separated off, the product was purified by chromatography.

Provenance & Evidence