HCID 19774261, compound → HCID 22018499, compound

HRID 1613652Notes

Reaction equation

HRID 1613652 reaction equation
C([NH:8][CH2:9][CH2:10][C:11]1[CH:21]=[CH:20][C:14]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:13][CH:12]=1)C1C=CC=CC=1>CO.[Pd]>[NH2:8][CH2:9][CH2:10][C:11]1[CH:21]=[CH:20][C:14]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:13][CH:12]=1

Participants

4

Reactant 1

HCID 19774261HCID 19774261, compound

Product 1

HCID 22018499HCID 22018499, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4'-(2-Benzylaminoethyl)methanesulfonanilide (XXIX.HCl) (8.0 g) and 20% Pd/C (0.5 g) were combined in MeOH (200 ml) and heated at 40° for 18 hours in a Parr hydrogenator under an average hydrogen pressure of 3 atmospheres. The catalyst was filtered off. Concentration of the filtrate caused precipitation of Compound (XXVIII).HCl, 5.5 g as a white solid, m.p. 244°-246° (decomp.), whose elemental analysis for C, H, and N, and NMR spectrum were consistent with the structure indicated.

Workup

  1. temperatureheated at 40° for 18 hours in a Parr hydrogenator under an average hydrogen pressure of 3 atmospheres
  2. filtrationThe catalyst was filtered off
  3. customprecipitation of Compound (XXVIII)

Sources & evidence

ORD record
ord-404c63211b7144929ca611adc56a4c94
Source dataset
uspto-grants-1993_03
Patent number
US05194450

Reaction notes

Loading…