Sulfuric Acid → Prop-2-yn-1-yl cyanoacetate

Participants

Reaction Steps

1.6 parts of propargyl alcohol and 1 part of cyanoacetic acid were dissolved in 4.7 parts of chloroform. 0.2 parts of a 98 percent by weight solution of aqueous sulfuric acid were added as a catalyst and the resultant mixture was heated for 5.5 hours at a temperature of 61° C. The crude ester was washed with water. Volatile materials were removed using reduced pressure. The ester, represented the formula N≡CCH2C(O)OCH2C≡CH, was isolated in 71 percent yield.

Provenance & Evidence