Benzyl Chloride → HCID 15611848, compound

HRID 1613692Notes

Reaction equation

HRID 1613692 reaction equation
[C:1]([O:9][CH2:10][CH2:11][N:12]([CH3:14])[CH3:13])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:15]([Cl:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(#N)C>[Cl-:22].[C:1]([O:9][CH2:10][CH2:11][N+:12]([CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([CH3:14])[CH3:13])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7503Benzyl ChlorideHCID 751582-Dimethylaminoethyl benzoate

Product 1

HCID 15611848HCID 15611848, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 57.96 g (0.30 mol) of 2-(N,N-dimethylamino)ethyl benzoate (prepared as described in Example 2), 37.98 g (0.30 mol) of benzyl chloride and 500 ml of acetonitrile was heated at reflux for 2 hours. The reaction mixture was concentrated to a white solid which was then washed with ether and recrystallized from acetonitrile. The yield of product was 69.0 g; mp=164°-6° C.

Workup

  1. temperatureat reflux for 2 hours
  2. concentrationThe reaction mixture was concentrated to a white solid which
  3. washwas then washed with ether
  4. customrecrystallized from acetonitrile

Sources & evidence

ORD record
ord-84d590e79f3f476caaae7133b1a97648
Source dataset
uspto-grants-1993_03
Patent number
US05194472

Reaction notes

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