1H-Benzimidazole-6-carboxamide → 1-(6-{[1-(3-fluorophenyl)ethyl]amino}pyrazin-2-yl)-1H-benzimidazole-6-carboxamide

Participants

Reaction Steps

In an analogous fashion, to Example 3, 6-chloro-N-[1-(3-fluorophenyl)ethyl]pyrazin-2-amine (025 g, 1 mmol) was reacted with 1H-benzimidazole-5-carboxamide (0.2 g, 1.2 mmol) to afford the product as a mixture of isomers. These were separated by chromatography using dichloromethane-methanol (98:2-92:8) as eluant to afford from the less polar fractions 1-(6-{[1-(3-fluorophenyl)ethyl]amino}pyrazin-2-yl)-1H-benzimidazole-6-carboxamide (80 mg).

Provenance & Evidence