反应详情

A solution of 49.6 g (0.248 mole) of 2-benzyloxyphenol, 22.2 g (0.3 mole) of glycidol, 2 ml of pyridine and 150 ml of absolute ethanol was heated at reflux overnight. The dark solution was concentrated to give an oil which gradually crystallized. The solid was purified by column chromatography on 1.2 kg of silica gel eluted with 0-25% acetone in benzene. Appropriate fractions were combined and concentrated to yield 49.5 g (73%) of the title compound as a white solid, mp 84°-85° C. (carbon tetrachloride) (lit.1 mp 81°-82.5° C.).

1. temperatureat reflux overnight
2. concentrationThe dark solution was concentrated
3. customto give an oil which
4. customgradually crystallized
5. customThe solid was purified by column chromatography on 1.2 kg of silica gel
6. washeluted with 0-25% acetone in benzene
7. concentrationconcentrated