Chlorosulfamic acid → 1-[2-[(Aminosulfonyl)oxy]ethyl]-2-pyrrolidinone

Participants

Reaction Steps

A solution of 6.5 g (0.05 mole) of 1-(2-hydroxyethyl)-2-pyrrolidone (Fluka) in 100 ml of methylene chloride was treated with 5.8 g (0.05 mole) of sulfamoyl chloride. The solution was stirred for 2 hr, then concentrated under vacuum. The residue was crystallized twice from 2-propanol to give 6.9 g (66%) of the title compound as white crystals, mp 110°-112° C. The compound was noted to be slightly hygroscopic.

Provenance & Evidence