HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 1-(6-[[1-(3-fluorophenyl)ethyl]amino]pyrazin-2-yl)-1H-benzimidazole-6-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 1-(6-{[1-(3-fluorophenyl)ethyl]amino}pyrazin-2-yl)-1H-benzimidazole-6-carboxamide | HCID 11257378 | — |
| Product | 1-(6-[[1-(3-fluorophenyl)ethyl]amino]pyrazin-2-yl)-1H-benzimidazole-6-carbonitrile | HCID 11439761 | 80% |
Reaction Steps
In an analogous procedure to that reported in Example 4, 1-(6-{[1-(3-fluorophenyl)ethyl]amino}pyrazin-2-yl)-1H-benzimidazole-6-carboxamide (83 mg 0.21 mmol) was reacted with phosphorus oxychloride to afford the product as a pale yellow solid (60 mg, 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07737143B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-0decf2fbbf764e13806159996ca3156c |
| Source note | uspto-grants-2010_06 |