Ammonia → 2-Amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazin

Participants

Reaction Conditions

Reaction Steps

4 4 g (0.259 mol) of gaseous ammonia were passed over the course of 45 minutes into a stirred mixture of 26.0 g (0.1293 mol) of 2,4-difluoro-6-trifluoromethoxy- 1,3,5-triazine and 100 ml of tetrahydrofuran at -70 to -65° C. The mixture was then stirred for 2 hours at -70° C. and overnight while warming to 22° C. The residue from concentration under reduced pressure was stirred with water, filtered off with suction and washed. Drying yielded 22 g (85.9% of theory) of the title compound of melting point 138-139° C.

Provenance & Evidence