Water → HCID 86746639, compound

Participants

Reaction Steps

A solution of 3,3-ethylenedioxy-20-formamido-16β-methylpregna-5,17(20)-diene-9α,21-diol (80 mg) in pyridine (0.25 ml) and acetic anhydride (0.12 ml) was stirred at room temperature for 7 hours after which TLC indicated the conversion to be complete. Methylene chloride and water were added to the reaction mixture. The organic phase was washed with water to neutral pH, dried and concentrated under reduced pressure to afford 50 mg of the title compound as a mixture of the two rotamer forms of the 20-formamido group.

Provenance & Evidence