Hydrochloric Acid → HCID 86746641, compound

Participants

Reaction Steps

To a solution of sodium (171 mg) in anhydrous methanol (10 ml) was added ethyl (20E)-20-chloro-3,3-ethylenedioxy-9α-hydroxypregna-5,17(20)-dien-21-oate (306 mg, as prepared in example 18), after which the reaction mixture was refluxed under nitrogen for 21 hours. The reaction mixture was cooled to room temperature. After adding methanol (20 ml) and water (10 ml) the mixture was neutralised with aqueous 5N hydrochloric acid. More water (30 ml) was added and a precipitate was formed. The solid was filtered, washed with water and dried to afford 46 mg of the title compound as a single isomer.

Provenance & Evidence