Water → HCID 67855816, compound

Participants

Reaction Conditions

Reaction Steps

Under nitrogen a 1M solution of diisobutylaluminium hydride in toluene (0.1 ml) was added to a stirred solution of methyl (20Z)-3,3-ethylenedioxy-9α-hydroxy-20-methoxypregna-5,17(20)-dien-21-oate (112 mg, prepared according to Example 19) in dry toluene (8 ml) at -20° C. The reaction mixture was stirred at -20° C. for 30 minutes. To complete the reaction the same quantity of diisobutylaluminium hydride solution was added and stirring was continued at -20° C. for 5 minutes. Next, water (2 ml) was added and the mixture was stirred at 0° C. for 1 hour. The heterogeneous mixture was filtered, then the filtrate was concentrated under reduced pressure to afford 66 mg of the title compound as a white solid.

Provenance & Evidence