Monobasic potassium phosphate → HCID 57069603, compound

Participants

Reaction Steps

Sodium borohydride (0.70 g) was added in small portions to a stirred solution of ethyl 20-cyano-3,3-ethylenedioxy-9α-hydroxypregna-5,17(20)-dien-21-oate (1.76 g) in dry tetrahydrofuran (15 ml). After stirring at room temperature for 5 hours, lithium aluminium hydride (0.12 g) was added in 3 portions and stirring was continued for 3 hours. Aqueous saturated potassium dihydrogen phosphate (15 ml) was added and the mixture was extracted with ethyl acetate. The organic extract was washed with aqueous sodium bicarbonate, then washed twice with water, dried and concentrated under reduced pressure to afford 0.82 g of the title compound.

Provenance & Evidence