HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Methyl 3-oxovalerate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Propionyl chloride | HCID 62324 | — |
| Reactant | Calcium Hydroxide | HCID 6093208 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | Methyl 3-oxovalerate | HCID 121699 | 89.9% |
Reaction Steps
Under the same conditions as in Example 1, 116 g (1.0 mol) of methyl acetoacetate in a mixture of 520 ml of methylene chloride and 30 ml of methyl ethyl ketone were reacted with 77.8 g (1.05 mol) of calcium hydroxide and 106.5 g (1.15 mol) of propionyl chloride. The pH in the subsequent reaction with ammonia was adjusted to 9.1. This gave 117 g (GC purity 79.0%) of methyl propionylacetate (yield 71.0%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05194671 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-6e055fee64424e8183db7b1e9b64ebfd |
| Source note | uspto-grants-1993_03 |