Hydrochloric Acid → HCID 178480374, compound

Participants

Reaction Steps

To a mixture of benzhydryl 7β-[2-(2-cyclopenten-1-yloxyimino)-2-(2-formamidothiazol-4-yl)acetamido]-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate trifluoroacetate (syn isomer, 4.9 g) in a mixture of methanol (50 ml) and tetrahydrofuran (10 ml)was added conc. hydrochloric acid (2.13 g) and the mixture was stirred at ambient temperature for 3 hours. Water (50 ml) and ethyl acetate (50 ml) were added thereto and the mixture was adjusted to pH 7.0 with 5% aqueous solution of sodium bicarbonate. The separated organic layer was washed with brine, dried over magnesium sulfate and evaporated to give benzhydryl 7β-[2-(2-aminothiazol-4-yl)-2-(2-cyclopenten-1-yloxyimino)acetamido]-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate chloride (syn isomer, 3.66 g).

Provenance & Evidence