1,2-Dibromoethane → 4-Hydroxypyrimidine

HRID 1614104Notes

Reaction equation

HRID 1614104 reaction equation
[N:1]1[CH:6]=[CH:5][C:4](=[O:7])[NH:3][CH:2]=1.Br[CH2:9][CH2:10][Cl:11].BrCCBr>>[O:7]=[C:4]1[N:3]([CH2:9][CH2:10][Cl:11])[CH:2]=[N:1][CH:6]=[CH:5]1.[N:1]1[CH:6]=[CH:5][C:4](=[O:7])[NH:3][CH:2]=1

Participants

5

Reactant 3

HCID 78391,2-DibromoethaneHCID 78491-Bromo-2-ChloroethaneHCID 206954-Hydroxypyrimidine

Product 2

HCID 206954-HydroxypyrimidineHCID 197725552-(1,6-Dihydro-6-oxopyrimidin-1-yl)ethyl chloride

Procedure

When an equivalent amount of 4-pyrimidone is substituted for 1-ethoxycarbonyl-2H-indazolin-3-one and 2-bromochloroethane is substituted for 1,2-dibromoethane in the procedure of Example 19, 2-(1,6-dihydro-6-oxopyrimidin-1-yl)ethyl chloride is isolated after column chromatography (4-pyrimidone, Aldrich, 34%, B).

Sources & evidence

ORD record
ord-7288ca43175e44ada9f8e8f8be5d7170
Source dataset
uspto-grants-1993_03
Patent number
USRE034201

Reaction notes

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