HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 4-(4-Chlorophenoxy)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 1-Chloro-4-(4-methoxyphenoxy)benzene | HCID 10105456 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-(4-Chlorophenoxy)phenol | HCID 12346120 | — |
Reaction Steps
The 4-(4'-chlorophenoxy)anisol was demethylated by refluxing it with an excess of 48% HBr in glacial acetic acid for 24 hours. The crude product, obtained after hydrolysis and extraction with diethyl ether, was recrystallized from hexane to yield 4-(4'-chlorophenoxy)phenol as a white solid, bp 83°-85° C., 24.5 g (91.4%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05196130 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-cfb74ed407ea4b96af2017d8eb1a94ef |
| Source note | uspto-grants-1993_03 |