反应详情

The hydroxypyrimidinone of Example 60 (0.2 g, 0.61 mmol) is dissolved in 5 ml ethanol, treated with 2.5 ml 1N NCl and refluxed for 6 hours. The reaction is cooled to room temperature, quenched with water and the product extracted 3× ethyl acetate. The organics are washed, dried, filtered and concentrated in vacuo to yield a crude substance which is crystallized from ethyl acetate to give 60 ml (31.5%) of the pyrimidinone as a crystalline solid. This material is a 7:3 mixture of endo-exo bicycloalkyl isomers.

1. additiontreated with 2.5 ml 1N NCl
2. temperaturerefluxed for 6 hours
3. customquenched with water
4. extractionthe product extracted 3× ethyl acetate
5. washThe organics are washed
6. customdried
7. filtrationfiltered
8. concentrationconcentrated in vacuo
9. customto yield a crude substance which
10. customis crystallized from ethyl acetate