HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 15881114, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 2,2-Dimethyl-1,3-dioxane-4,6-dione | HCID 16249 | — |
| Reactant | 5-Bromoindole | HCID 24905 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 15881114 | HCID 15881114 | 417.3% |
Reaction Steps
A solution of 5-bromoindole (10.07 g, 51 mmol), Meldrum's acid (7.38 g, 51 mmol), proline (1.24 g), and 5.2 ml of 30% aqueous formaldehyde in 100 ml of acetonitrile was allowed to stand at room temperature for 24 hours. The acetonitrile was removed in vacuo. Crystallization of the product from methanol (50 ml) provided 15.83 g of 3-(2,2-dimethyl-4,6-dioxo-1,3-dioxane-5-yl)methyl-5-bromoindole as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05196427 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-c014d8ab7045482ab5200cc8f45f0a0f |
| Source note | uspto-grants-1993_03 |