Citric Acid → HCID 178512808, compound

HRID 1614227Notes

Reaction equation

HRID 1614227 reaction equation
Cl.Cl.[NH:3]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([NH2:15])=[O:14])[C:4]([NH2:6])=[NH:5].Cl.Cl.[NH2:18][CH2:19][CH2:20][CH2:21][NH:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:27][C:28](=[O:32])[CH:29](O)[OH:30].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O>[NH2:18][CH2:19][CH2:20][CH2:21][NH:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:27][C:28](=[O:32])[CH:29]([NH:15][C:13](=[O:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][NH:3][C:4]([NH2:6])=[NH:5])[OH:30]

Participants

5

Reactant 3

HCID 311Citric AcidHCID 133564GlyoxylylspermidineHCID 178478811HCID 178478811, compound

Product 1

HCID 178512808HCID 178512808, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
60 °C

Procedure

A mixture of 10.0 g (45.0 m moles) of 7-guanidinoheptanamide dihydrochloride, 13.1 g (45.0 moles) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride, and 3.2 g (15 m moles) of citric acid in water (100 ml) was evaporated to dryness to give a syrup which contained 1.0 g of water. The resulting syrup was heated at 60° C. for 8 hours.

Workup

  1. customwas evaporated to dryness
  2. customto give a syrup which

Sources & evidence

ORD record
ord-ef44020a2ca442598dfcd31f11b5e7c9
Source dataset
uspto-grants-1993_03
Patent number
US05196453

Reaction notes

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