Allyl bromide → HCID 19773037, compound

Participants

Reaction Steps

Ethyl 3,5-dihydroxybenzoate was reacted in turn with 2-bromomethylnaphthalene and allyl bromide using the conditions described in Example 1 to give ethyl 5-allyloxy-3-(naphth-2-ylmethoxy)benzoate in 15% yield, as an oil. Following the procedures described in the portion of Example 3 which is concerned with the preparation of starting materials the product so obtained was reacted with thiazol-2-yl-lithium to give 5-allyloxy-3-(naphth-2-ylmethoxy)phenyl 2-thiazolyl ketone in 52% yield, m.p. 65°-67° C., and that product was reacted with ethylmagnesium to give the required starting material in 49% yield, as a gum.

Provenance & Evidence