Potassium Iodide → 1-Iodo-3-methoxy-5-(trifluoromethyl)benzene

Participants

Reaction Steps

Using conventional procedures 3-methoxy-5-trifluoromethylaniline (J. Chem. Soc., 1951, 2013) was diazotised and reacted with potassium iodide to give 3-methoxy-5-trifluoromethyliodobenzene, as an oil. The product so obtained was reacted with boro tribromide using the conditions described in Note b. above to give 3-hydroxy-5-trifluoromethyliodobenzene in 95% yield, as an oil. The product so obtained was reacted with 2-bromomethylnaphthalene using the conditions described in Example 1 to give 3-(naphth-2-ylmethoxy)-5-trifluoromethyliodobenzene in 62% yield, m.p. 65°-66° C.

Provenance & Evidence