HCID 19773275, compound → HCID 19773293, compound

Participants

Reaction Steps

1.40 g (0.0041 mol) of 5-acetylamino-2-(N-benzyl-N-methylamino)-tetraline-hydrochloride (Example 4.1.26) are hydrogenated in 50 ml of methanol in the presence of 0.4 g of 10% palladium/charcoal at 60° C. under a pressure of 4 bar until the uptake of hydrogen has ceased. After the catalyst has been removed by suction filtering, the residue is concentrated by rotary evaporation, finally at 80° C. under a complete water-jet vacuum. The residue is crystallised from 15 ml of methanol and 15 ml of diethylether. After suction filtering, washing with methanol/ether and drying at 80° C. the title compound is obtained in a yield of 0.85 g (81.5% of theory) and with a melting point of 253° C., which does not change after recrystallisation from methanol/ether.

Provenance & Evidence