HCID 11106474, compound → HCID 19773270, compound

HRID 1614268Notes

Reaction equation

HRID 1614268 reaction equation
C(NC1C=CC=C2C=1CCC(N)C2)(=[O:3])C.Cl.[C:17]([NH:20][C:21]1[CH:30]=[CH:29][CH:28]=[C:27]2[C:22]=1[CH2:23][CH2:24][CH:25]([NH:31][CH2:32][C:33]1[CH:38]=CC=CC=1)[CH2:26]2)(=[O:19])[CH3:18]>>[C:17]([NH:20][C:21]1[CH:30]=[CH:29][CH:28]=[C:27]2[C:22]=1[CH2:23][CH2:24][CH:25]([NH:31][C:32](=[O:3])[CH2:33][CH3:38])[CH2:26]2)(=[O:19])[CH3:18]

Participants

3

Reactant 2

HCID 11106474HCID 11106474, compoundHCID 19773329HCID 19773329, compound

Product 1

HCID 19773270HCID 19773270, compound

Procedure

Starting from 12.3 g (0.06 mol) of 5-acetylamino-2-amino-tetraline (known substance prepared by debenzylation of 5-acetylamino-2-benzylamino-tetraline (Example 4.1.16) analogously to Example 4.4.1) the title compound is obtained by propionylation analogously to Example 4.5.1 a) in a yield of 13.5 g (86.3% of theory).

Sources & evidence

ORD record
ord-958fe57b35704fd8a8276aa6d3d0f06b
Source dataset
uspto-grants-1993_03
Patent number
US05196454

Reaction notes

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