Potassium Hydroxide → HCID 19773374, compound

Participants

Reaction Steps

0.50 g (1.92 mmol) of 5-(N-acetyl-N-methyl-amino)-2-n-propylamino-tetraline-hydrochloride (Example 4.7.8) are stirred with 12.5 g (0.22 mol) of potassium hydroxide in 40 ml of diethyleneglycol for 24 hours at 150° C. The mixture is then cooled, diluted with 400 ml of water and extracted three times with ethyl acetate (50, 15 and 15 ml). The combined extracts are washed with 20 ml of water, dried with sodium sulphate and, after the drying agent has been filtered off, concentrated by rotary evaporation, finally at 80° C. under a complete water-jet vacuum. The residue is crystallised as the hydrochloride analogously to Example 4.1.1. The title compound is obtained in a yield of 0.39 g (69.7% of theory) and with a melting point of 245° C. which does not change when recrystallised from ethanol/ether.

Provenance & Evidence