HCID 19773377, compound → HCID 19773412, compound

Participants

Reaction Steps

Starting from 0.56 g (1.89 mmol) of 5-(N-acetyl-N-methyl-amino)-2-n-propylamino-tetraline-hydrochloride (Example 4.7.8) which is converted into the base, the title compound is obtained as a base by reduction in 20 ml of absolute tetrahydrofuran analogously to Example 4.5.1 c), but using 1.90 ml of 2-molar diboran solution in tetrahydrofuran (THF) as reducing agent. The base is purified by column chromatography (50 g of silica gel, methylene chloride/methanol/conc. ammonia 90:10:0.5) and crystallised as the dihydrochloride analogously to Example 4.1.1, in a yield of 0.33 g (54.6% of theory) and with a melting point of 200° C.

Provenance & Evidence