HCID 19773325, compound → HCID 19773360, compound

Participants

Reaction Steps

Starting from 1.03 g (0.0033 mol) of 5-(N-acetyl-N-ethylamino)-2-n-propylamino-tetraline-hydrochloride (Example 4.7.8) which is converted into the base, the title compound is obtained in base form by reduction in 30 ml of absolute tetrahydrofuran analogously to Example 4.5.1 c), but using 3.3 ml of 2-molar diborandimethylsulphide complex solution in tetrahydrofuran as the reducing agent. This base is purified by filtering over 16 g of aluminium oxide (activity stage III, neutral) using methylene chloride as solvent and is crystallised analogously to Example 4.1.1 in the form of the dihydrochloride which is obtained in a yield of 0.54 g (49.1%) and with a melting point of 201° C.

Provenance & Evidence