HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium cyanoborohydride → 5-Acetylamino-2-(1-phenylethylamino)-tetraline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | (R)-1-phenylethylamine hydrochloride | HCID 12236043 | — |
| Reactant | 5-Acetylamino-2-tetralone | HCID 14836456 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Acetylamino-2-(1-phenylethylamino)-tetraline | HCID 14836573 | — |
Reaction Steps
Starting from 16.24 g (0.08 mol) of 5-acetylamino-2-tetralone, 240 ml of methanol, 19.0 g (0.12 mol) of (R)-1-phenylethylamine-hydrochloride and 6.0 g (0.096 mol) of sodium cyanoborohydride, the title compound is obtained analogously to Example 4.1.11 and is crystallised from 75 ml of toluene. Yield 18.5 g (74.9% of theory), melting point 158° C. It consists of approximately equal parts of the (R/R)- and (S/R)-diastereoisomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05196454 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-144797a8ca3f40acb26de6f610413971 |
| Source note | uspto-grants-1993_03 |