反应详情

Dimethylsulphate (2.28 ml) was added over 5 min to a stirred mixture of 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one (3 g), acetone (12 ml) and 20% w/v aqueous sodium hydroxide (9 ml) at ca. 50°. The mixture was heated at reflux for 10 min. Further sodium hydroxide (6 ml) was added and the mixture was heated at reflux for 5 min. On cooling a solid crystallised. Water (10 ml) was added and the mixture was filtered. The solid was washed with water (2×20 ml), and dried in vacuo 45° to give the title compound (3.16 g). The t.l.c. data for this material were consistent with those obtained for the product of Example 1.

1. customat ca. 50°
2. temperatureThe mixture was heated
3. temperatureat reflux for 10 min
4. temperaturethe mixture was heated
5. temperatureat reflux for 5 min
6. temperatureOn cooling a solid
7. customcrystallised
8. additionWater (10 ml) was added
9. filtrationthe mixture was filtered
10. washThe solid was washed with water (2×20 ml)
11. customdried in vacuo 45°