反应详情

17 g (0.04982 mol) of methyl N-[4-(4-bromophenyl)-2-thiazolyl]-N-methylamino-acetate and 17.4 g (0.1078 mol) of t-butoxy-bis-(dimethylamino)-methane are stirred for 6 hours at 100° C., the mixture is cooled, treated with ice-water and stirred for a few hours at room temperature, and precipitated crystals are filtered off with suction and dried. 17.5 g (89% of theory) of methyl 2-{N-[4-(4-bromophenyl)-2-thiazolyl]-N-methylamino}-3-dimethylaminoacrylate of melting point 184°-185° C. are obtained.

1. temperaturethe mixture is cooled
2. customprecipitated crystals
3. filtrationare filtered off with suction
4. customdried