HCID 67793175, compound → HCID 67792513, compound

HRID 1614331Notes

Reaction equation

HRID 1614331 reaction equation
[CH3:1][O:2][C@H:3]1[C@@H:8]([CH2:9][CH2:10][OH:11])[CH2:7][CH2:6][N:5](CC2C=CC=CC=2)[CH2:4]1.[H][H]>[Pd].CO>[CH3:1][O:2][C@H:3]1[C@@H:8]([CH2:9][CH2:10][OH:11])[CH2:7][CH2:6][NH:5][CH2:4]1

Participants

5

Reactant 2

HCID 67793175HCID 67793175, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67792513HCID 67792513, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 25.9 parts of cis-3-methoxy-1-(phenylmethyl)-4-piperidineethanol (prepared as in EP-A-0,320,032) and 198 parts of methanol was hydrogenated at normal pressure and 50° C. with 3 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 16.5 parts (100%) of cis-3-methoxy-4-piperidineethanol (interm. 45).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-3be8f3b9519e43f8b983c1e2eb5a076d
Source dataset
uspto-grants-1993_03
Patent number
US05196535

Reaction notes

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