Dimethylcarbamoyl Chloride → HCID 15136699, compound

Participants

Reaction Steps

1-Benzyl-4,4-dimethyl-3-pyrazolidinone [1.2 g] and dimethylcarbamoyl chloride [0.56 mL] were combined in 4 mL pyridine and 1.5 mL triethylamine. The resulting mixture was stirred at room temperature for 16 h. The reaction mixture was diluted with ethyl acetate (50 mL), washed with saturated ammonium chloride solution (30 mL), dried over MgSO4, and evaporated. Chromatography on silica gel gave 0.6 g (37%) of pure 1-benzyl-4,4-dimethyl-3-(N,N-dimethylcarbamoyloxy)-2-pyrazoline as a light yellow oil. 1H NMR: 7.6-7.2 (5H, m), 3.8-3.4 (4H, m), 3.2 (6H, s), 1.2 (6H, s).

Provenance & Evidence