反应详情

1600 mg of the thus-obtained diacetylene compound were then dissolved in 300 ml of benzene, and 450 mg of potassium hydroxide were then added to the reaction mixture, followed by reflux under heating for 1 hour. After filtration, the solvent was evaporated, and the residue was then purified by silica-gel column chromatography using benzene as an eluent to obtain 500 mg of 1-[3-(N-methylamino)phenyl]-1,3-butadiyne.

1. temperatureby reflux
2. temperatureunder heating for 1 hour
3. filtrationAfter filtration
4. customthe solvent was evaporated
5. customthe residue was then purified by silica-gel column chromatography