HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-chloro-5-(trifluoromethyl)benzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Nitrophenol | HCID 980 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Chloro-2-fluoro-5-(trifluoromethyl)benzoic acid | HCID 2773751 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-chloro-5-(trifluoromethyl)benzoic Acid | HCID 3802362 | — |
Reaction Steps
3-Chloro-2-fluoro-5-(trifluoromethyl)benzoic acid and an equimolar amount of p-nitrophenol are stirred with an equimolar amount of anhydrous potassium carbonate in dimethylsulfoxide at 110° C. for 24 hours and then left overnight at room temperature. The mixture is then poured into dilute hydrochloric acid and the solid is recovered and purified by dissolving, washing and drying to give 4'-nitrophenoxy ether at the 2-position of 3-chloro-5-(trifluoromethyl)benzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05196593 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-3a70ecf1631345938d53cce05d7588da |
| Source note | uspto-grants-1993_03 |