1,1,1,3,3-Pentafluoro-2,3-dichloro-2-(4-ethoxyphenyl)propane → 1,1,1,3,3-Pentafluoro-2-(4-ethoxyphenyl)prop-2-ene

Participants

Reaction Conditions

Reaction Steps

A solution of 1,1,1,3,3-pentafluoro-2,3-dichloro-2-(4-ethoxyphenyl)propane (29.5 g) in methanol (40 cm3) was added dropwise to a suspension of zinc powder (9.1 g) and zinc chloride (0.45 g) in methanol (80 cm3) whilst the temperature was maintained at 35° C. After the addition was complete the mixture was stirred at the ambient temperature (ca. 23° C.) for 2 hours. After dilution with water and filtering off the zinc, the mixture was extracted with chloroform, the extracts washed with water, dried over anhydrous magnesium sulphate and concentrated by evaporation of the solvent to yield 1,1,1,3,3-pentafluoro-2-(4-ethoxyphenyl)prop-2-ene (19.0 g) as a mobile liquid.

Provenance & Evidence