Sulfuric Acid → HCID 14517057, compound

HRID 1614452Notes

Reaction equation

HRID 1614452 reaction equation
S(=O)(=O)(O)O.[F:6][C:7]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:8]=1[O:9][C:10]1[CH:11]=[C:12]([CH:16]2OCC[O:17]2)[CH:13]=[CH:14][CH:15]=1>CC(C)=O>[F:6][C:7]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:8]=1[O:9][C:10]1[CH:11]=[C:12]([CH:13]=[CH:14][CH:15]=1)[CH:16]=[O:17]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 14517056HCID 14517056, compound

Product 1

HCID 14517057HCID 14517057, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
55 °C

Procedure

Concentrated sulphuric acid (0.18 g) was added to a solution of 2-(3-(2,4-difluorophenoxy)phenyl)-1,3-dioxolane in acetone (200 cm3). The stirred mixture was heated at 55° C. for 5 hours. After cooling, the solvent was evaporated under reduced pressure, and the residue neutralised by addition of an aqueous solution of sodium hydrogen carbonate. This aqueous mixture was partitioned between diethyl ether and water. The ether layer was separated, dried over anhydrous magnesium sulphate and the solvent evaporated under reduced pressure to give 3-(2,4-difluorophenoxy)benzaldehyde as an oil (6.4 g). The product was shown to be 85% pure by gas liquid chromatography, and was used without further purification.

Workup

  1. temperatureAfter cooling
  2. customthe solvent was evaporated under reduced pressure
  3. additionthe residue neutralised by addition of an aqueous solution of sodium hydrogen carbonate
  4. customThis aqueous mixture was partitioned between diethyl ether and water
  5. customThe ether layer was separated
  6. dry with materialdried over anhydrous magnesium sulphate
  7. customthe solvent evaporated under reduced pressure

Sources & evidence

ORD record
ord-81305acec66744e0972f94f77675848e
Source dataset
uspto-grants-1993_03
Patent number
US05196610

Reaction notes

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