反应详情

Succinic acid (885 mg) is dissolved in methanol (10 ml). A solution of the title compound from Example 65 (950 mg) in methanol (5 ml) is added to the succinic acid solution in one portion. The solution is stirred at 20°-25° for 45 minutes and then the methanol is partially removed by evaporation at a reduced pressure. Next, ether is added to the partially evaporated solution and a white precipitate forms. The solid is collected by filtration. The solid is recrystallized from acetonitrile twice to yield the title compound, mp 148°-149° C. (PLA2, diabetes-)

1. customthe methanol is partially removed by evaporation at a reduced pressure
2. additionNext, ether is added to the partially evaporated solution
3. filtrationThe solid is collected by filtration
4. customThe solid is recrystallized from acetonitrile twice