P-Toluenesulfonamide → HCID 131717833, compound

Participants

Reaction Conditions

Reaction Steps

Copper (II) acetate monohydrate (0.13 g, 0.00064 mol) and glucose monohydrate (1.6 g, 0.008 mol) are added to a mixture of bromaminic acid sodium salt (38.2 g, 0.1 mol) and p-toluenesulphonamide (18.8 g 0.11 mol) in water (250 mol) containing sodium carbonate (3.8 g) and sodium bicarbonate (19.0 g). The mixture which has a pH of 8.5-9.0, is heated to 70° C. and stirred at this temperature for five hours. The resulting mixture is diluted to a volume of 750 ml with water and cooled to 40° C. The solid product is filtered off and washed with a solution of sodium chloride (12 g) in water (1300 ml) to give a 97% yield 1-amino-4-(4'-methlylphenylsulphonamido)-anthraquinone-2-sulphonic acid sodium salt, a product of formula I where M denotes sodium and R denotes a group of formula IV.

Provenance & Evidence