HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 5-bromo-1,2 dihydro-2,2-dimethyl-6-(2-imidazolin-2-ylamino)-3-(4H)-quinoxalinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 4,5-dihydro-1H-imidazole-2-sulfonic acid | HCID 274561 | — |
| Reactant | 6-Amino-5-bromo-1,2-dihydro-2,2-dimethyl-3-(4h)-quinoxalinone hydrobromide | HCID 19936405 | — |
| Solvent | Isobutanol | HCID 6560 | — |
| Product | 5-bromo-1,2 dihydro-2,2-dimethyl-6-(2-imidazolin-2-ylamino)-3-(4H)-quinoxalinone | HCID 15225715 | — |
Reaction Steps
A mixture of 6-amino-5-bromo-1,2-dihydro-2,2-dimethyl-3-(4H) - quinoxalinone hydrobromide (479 mg, 1 mmol) and 2-imidazoline-2-sulfonic acid (224 mg, 1.5 mmol) in isobutanol (5 ml) is heated at reflux until the starting hydrobromide material is consumed. The solvent is removed in vacuo and the residue chromatographed on silica gel with CHCl3 : CH3OH saturated with NH3 (g) elution to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05198442 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-5e284c4625ad4d8ca1c9e107b11db3fd |
| Source note | uspto-grants-1993_03 |