Sodium hydride → HCID 53998497, compound

Participants

Reaction Steps

To a suspension of 9.68 g of 60% sodium hydride in 50 ml of anhydrous DMF, there is slowly added a solution of 44.9 g of 3-(3-hydroxy propyl) 1,2-dihydro 2-oxo quinoxaline (obtained in accordance with 1.1) in 450 ml of DMF. The solution is agitated until completion of the liberation of hydrogen, whereupon 36 g of prenyl bromide are added. The resultant solution is agitated overnight at room temperature and then evaporated to dryness under reduced pressure. The brown residue is treated with 150 ml of water and 400 ml of methylene chloride. After evaporation under vacuum, a beige solid is obtained which is recrystallized from 200 ml of toluene. In this way there are isolated 33.8 g of compound 1 in the form of pale yellow crystals.

Provenance & Evidence