4-Phenylbutyric Acid → HCID 9859422, compound

Participants

Reaction Steps

5 mmol of 4-phenyl butyric acid, 5 mmol of 1,2,3,6-tetrahydropyridine, and 6 mmol of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride were mixed with 20 ml of methylene chloride. The mixture was reacted for 2 hours at room temperature with stirring. The reaction mixture was washed with 5% hydrochloric acid, 2% sodium hydroxide, and brine. The organic layer was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by column chromatography on silica gel to obtain 950 mg of colorless crystals of N-(4-phenylbutanoyl)-1,2,3,6-tetrahydropyridine (yield: 83%).

Provenance & Evidence