Hydrochloric Acid → HCID 178428932, compound

Participants

Reaction Steps

Concentrated hydrochloric acid (0.75 ml) was added to a solution of 7,8-dihydro-2-methyl-4-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl)methoxy]-5H-pyrano[4,3-b]pyridine (A1) (0.94 g) in ethanol (6 ml) and methanol (3 ml). The solution was left to stand for 18 hours, and the precipitated solid collected by filtration, and washed with ether to give 7,8-dihydro-2-methyl-4-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methoxy]-5H-pyrano[4,3-b]-pyridine hydrochloride (0.47 g), as a white solid, m.p. 173°-175° C.; NMR (d6 -DMSO): 2.7(s,3H), 3.0(t,2H), 3.95(t,2H), 4.7(s,2H), 5.4(s,2H), 7.2(d,2H), 7.4(d,2H), 7.5-7.75 (complex m,5H); 13C NMR (d6 -DMSO): 71.0 (benzylic CH2); mass spectrum (negative fast atom bombardment (-ve FAB), DMSO/Glycerol (GLY)): 398 (M-H)- ; microanalysis, found: C,62.8; H,4.9; N,15.9; H2O, 0.9%; C23H21N5O2.HCl.0.25H2O requires C,62.7; H,5.1; N,15.9; H2O 1.0%.

Provenance & Evidence