Isopropyl iodide → HCID 19772016, compound

Participants

Reaction Steps

A mixture of 34.16 g (0.165 mol) of the 4-(4-fluorobenzoyl)piperidine, 33.80 g (0.199 mol) of isopropyl iodide and excessive sodium bicarbonate in 600 mL of acetonitrile was heated at reflux for 14 h. The solvent was removed in vacuo, and the residue was partitioned between CH2Cl2 and dilute NaOH. The CH2Cl2 solution was dried (Na2SO4), and the solvent was removed in vacuo to give a solid. This was recrystallized from CH2Cl2 /hexane to give 31.89 g (77.6%) of crystalline solid, mp 120°-121° C.

Provenance & Evidence