Benzene, (3-bromopropoxy)- → 2-Cyano-1-(3-phenoxypropyl)pyrrolidine

HRID 1614611Notes

Reaction equation

HRID 1614611 reaction equation
[C:1]([CH:3]1[CH2:7][CH2:6][CH2:5][NH:4]1)#[N:2].[O:8]([CH2:15][CH2:16][CH2:17]Br)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[C:1]([CH:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:17][CH2:16][CH2:15][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)#[N:2]

Participants

3

Reactant 2

HCID 68522Benzene, (3-bromopropoxy)-HCID 4712728Pyrrolidine-2-carbonitrile

Product 1

HCID 197719832-Cyano-1-(3-phenoxypropyl)pyrrolidine

Procedure

Following the procedure of Preparation 9, the title compound is prepared from 2-cyanopyrrolidine [Helv. Chim. Acta 50(8), 2520-2531 (1967)] and 3-phenoxypropyl bromide.

Workup

  1. customthe procedure of Preparation 9

Sources & evidence

ORD record
ord-bfbba604a72e47869c6276f2c9d0ef2b
Source dataset
uspto-grants-1993_03
Patent number
US05198449

Reaction notes

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